End-to-end CAR-T manufacturing — from leukapheresis processing through T cell activation, viral transduction, expansion, and cryopreservation. Autologous and allogeneic programs, from IND-enabling through commercial supply.
CAR-T is the most mature cell therapy modality — 312 companies, 185 clinical stage, 317 active trials. Manufacturing scale, vector supply, and vein-to-vein time are the differentiators. Made Scientific provides comprehensive manufacturing support for autologous and allogeneic CAR-T programs with the speed, precision, and GMP compliance your program demands.
Comprehensive manufacturing support for autologous and allogeneic CAR-T programs — from process development through commercial-scale production.
T cell activation optimization, transduction protocol development, expansion kinetics, and process lock — tailored to your specific CAR construct.
Lentiviral and retroviral vector production — or partnership-based procurement — ensuring your program is never bottlenecked by vector availability.
Purpose-built cleanroom suites with full chain-of-identity/chain-of-custody tracking — critical for autologous patient-specific products.
CAR expression (flow cytometry), transduction efficiency, T cell phenotyping, potency assays, sterility, VCN, and release testing.
From single-patient clinical batches to high-throughput commercial manufacturing — process comparability, capacity planning, and multi-product suites.
IND-enabling manufacturing, CMC documentation, process validation, and regulatory strategy — from pre-IND through BLA filing.
Every step of CAR-T manufacturing — from apheresis material receipt to cryopreserved product — executed in our GMP facilities with full chain-of-identity tracking.
Incoming material processing, T cell enrichment, and quality assessment
Anti-CD3/CD28 activation, cytokine conditioning, and activation confirmation
Lentiviral or retroviral CAR gene transfer with transduction efficiency monitoring
CAR-T cell expansion to clinical dose in bioreactors with phenotype monitoring
Harvest, wash, formulation for cryopreservation with in-process QC
Controlled-rate freezing, QC release testing, storage, and distribution
Our GMP facilities are designed specifically for cell therapy and actively support concurrent programs across development stages.
Made Scientific Headquarters
Located at the heart of innovation in Princeton, New Jersey, our 60,000 ft² facility is equipped to take your therapy from early development to GMP manufacture.
Made Scientific Clinical Production
Strategically designed for flexibility, our Newark site offers 15,000 ft² of GMP-ready space to support client-dedicated and hybrid operational models.
Workforce Development & Training
We're investing in the future of cell therapy through both hands-on and digitally accessible GMP-inspired training. Located on the NJIT campus, our center has supported over 275 trainees across industry and academia.
Flexible engagement models for every stage — from early process development through multi-product commercial manufacturing.
All Clients
Full-service CAR-T manufacturing. We execute the entire vein-to-vein process in our GMP suites — your team maintains oversight, we deliver product.
Mid-to-Late Stage Clients
Your scientists work alongside ours during tech transfer and process optimization. Builds deep manufacturing knowledge while maintaining your process expertise.
Late-Stage and Commercial Clients
Dedicated CAR-T suites configured for your program — from closed-system processing to custom automation and high-throughput commercial capacity.
Currently advancing autologous and allogeneic CAR-T programs from process development through GMP manufacturing, with real-world experience across the vein-to-vein workflow.
In-house and partnership-based vector procurement ensures your CAR-T program is never bottlenecked by vector availability — coordinated with manufacturing timelines.
Purpose-built infrastructure for patient-specific manufacturing — chain-of-identity tracking, dedicated suites, and scheduling systems designed for vein-to-vein urgency.
Multi-product suites and high-throughput capacity planning — structured to support the transition from clinical batches to commercial manufacturing volumes.
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